Cell_Articles in Press
订阅

Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages

Mills et al. demonstrate how the mitochondria is repurposed from ATP production to ROS generation in order to support the pro-inflammatory function of macrophages.

2016-09-23

Loss of IFN-γ Pathway Genes in Tumor Cells as a Mechanism of Resistance to Anti-CTLA-4 Therapy

Genomic defects in the interferon pathway genes reduce the chance of response to immune checkpoint blockade therapy with anti-CTLA-4 for melanoma in humans and experimental models.

2016-09-23

Potent, Reversible, and Specific Chemical Inhibitors of Eukaryotic Ribosome Biogenesis

Selective potent inhibitors of eukaryotic ribosome biogenesis are found through a chemical synthetic lethal screen.

2016-09-23

Mutations in Human Accelerated Regions Disrupt Cognition and Social Behavior

Mutations in genomic loci that have undergone accelerated evolution in humans are associated with increased risk for autism.

2016-09-23

A Functional Role for Antibodies in Tuberculosis

Individuals with active and latent tuberculosis (TB) infections can be distinguished by the type of antibodies they produce, pointing toward an important and unappreciated contribution from humoral immunity in controlling chronic TB.

2016-09-23

Type VI Secretion System Substrates Are Transferred and Reused among Sister Cells

Bacteria use proteinaceous spear guns to attack one another and can reuse the components that entered their cytosol in this manner.

2016-09-09

Warm-Sensitive Neurons that Control Body Temperature

A specific population of neurons regulates body temperature in mammals by coordinating the behavioral and autonomic response to heat.

2016-09-09

Development of a Comprehensive Genotype-to-Fitness Map of Adaptation-Driving Mutations in Yeast

How can the entire suite of adaptive mutations that occur in an evolving population be pinpointed and each of their fitness effects measured?

2016-09-02

Polar Positioning of Phase-Separated Liquid Compartments in Cells Regulated by an mRNA Competition Mechanism

Asymmetric positioning of cellular compartments formed by phase separation can be driven by competition between two mRNA binding proteins, one of which forms a spatial concentration gradient.

2016-09-02

A Genome-wide CRISPR Screen in Identifies Essential Apicomplexan Genes

The first genome-wide genetic screen of an apicomplexan parasite identifies an invasion factor essential for the fitness of all parasites in this phylum, including those causing malaria and toxoplasmosis.

2016-09-02

Nuclear Pore Permeabilization Is a Convergent Signaling Event in Effector-Triggered Immunity

Rather than being a passive conduit, the nuclear pore complex, in response to immune signals, undergoes a conformational switch to reconfigure the selective barrier and promote stress signaling.

2016-08-30

γδ T Cells Support Pancreatic Oncogenesis by Restraining αβ T Cell Activation

γδT cells are key regulators of effector T cell activation in pancreatic cancer and a new target for cancer immunotherapy.

2016-08-30

Massively Parallel Interrogation of the Effects of Gene Expression Levels on Fitness

How does gene expression variation affect fitness? Systematic probing informs gene function, optimality of wild-type expression, and the impact of noise.

2016-08-24

The Spectrum and Regulatory Landscape of Intestinal Innate Lymphoid Cells Are Shaped by the Microbiome

The gut ILC population is a lot more diverse than we thought, and this diversity requires constant signaling from the local microbiota.

2016-08-24

Cellular Cholesterol Directly Activates Smoothened in Hedgehog Signaling

Although Smoothened can bind to several different sterols, cholesterol serves as its endogenous activator, driving a conformational change in the protein that enables Hedgehog signaling.

2016-08-24

The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity

A homozygous hypomorphic mutation in the deubiquitinase OTULIN causes a potentially fatal autoinflammatory disorder, which is reconciled in mouse models.

2016-08-16

Live Cell Imaging Reveals the Dynamics of Telomerase Recruitment to Telomeres

Live cell imaging studies reveal how telomerase scouts for telomeres in the 3D nuclear space through multiple dynamic touch-and-go interactions.

2016-08-16

Glycosylation-Dependent IFN-γR Partitioning in Lipid and Actin Nanodomains Is Critical for JAK Activation

Membrane nanodomains can control transmembrane receptor signaling by permitting conformational changes needed for activation.

2016-08-08

GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling

Megaplexes containing a GPCR simultaneously engaged with a G protein and β-arrestin sustain G protein signaling following internalization into endosomes.

2016-08-08

Memory of Inflammation in Regulatory T Cells

Most inflammation-induced changes in Treg cell transcriptome, epigenome, and function are transient. A largely reversible activation state may enable potentiation of Treg cell function under inflammatory conditions, while avoiding long-lasting immunosuppression.

2016-08-08
热门期刊